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Testogen 100

Testosterone propionate is a slower releasing anabolic steroid with a short half-life. This characteristic allows the user to run short testosterone propionate cycles of 8-10 weeks as optimal peak blood plasma levels are achieved at 2-4 weeks.4 It is a synthetic androstane steroid derivative of testosterone in the form of 17β propionate ester of testosterone.2 Testosterone propionate was developed initially by Watson labs, and FDA approved on February 5, 1974. Currently, this drug has been discontinued in humans, but the vet application is still available as an OTC.5

SKU: 01-2 Category:

Description

Testosterone propionate is a slower releasing anabolic steroid with a short half-life. This characteristic allows the user to run short testosterone propionate cycles of 8-10 weeks as optimal peak blood plasma levels are achieved at 2-4 weeks.4 It is a synthetic androstane steroid derivative of testosterone in the form of 17β propionate ester of testosterone.2 Testosterone propionate was developed initially by Watson labs, and FDA approved on February 5, 1974. Currently, this drug has been discontinued in humans, but the vet application is still available as an OTC.5
Type
Small Molecule
Groups
Approved, Investigational, Vet approved, Withdrawn
Structure
Thumb

3D
Similar Structures
Weight
Average: 344.4877
Monoisotopic: 344.23514489
Chemical Formula
C22H32O3
Synonyms
Testosterone propionate
External IDs
NRB-03689
NSC-9166
PHARMACOLOGY
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Indication
Testosterone propionate is often used for muscle mass building. The original medical indication is for the treatment of androgen deficiency in male adults either in hypogonadism or andropause.6 Nowadays testosterone propionate is indicated for its use in heifers in order to stimulate maximal growth.5
Associated Conditions
Breast Cancer
Puberty, Delayed
Testosterone Deficiency
Hematomas
Contraindications & Blackbox Warnings
Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects
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Pharmacodynamics
The administration of testosterone propionate can induce production of proteins related to male sexual development.7 On the other hand, testosterone itself present an estrogenic activity due to interaction with aromatase enzyme, thus the continuous aministration of testosterone propionate may cause the elevation of plasma estrogen.6 Clinical trials showed as well, a decrease in plasma LH after testosterone propionate administration.1
Mechanism of action
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5alpha-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5alpha-reductase. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

TARGET
ACTIONS
ORGANISM
AAndrogen receptor
agonist
Humans
Absorption
Testosterone propionate presents a slow absorption from the intramuscular site of administration. This slow absorption is due to the presence of the less polar ester group.7 The absorption rate of testosterone propionate generates a frequent injection requirement when compared with testosterone enanthate or testosterone cypionate. It presents absorption parameters of AUC and residence time of 180-210 ng h/ml and 40-60 h, respectively.1

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